Nucleic Acid BCT™
All Your Workflows in One Tube!
Human blood is a treasure trove of genetic information, hosting crucial details within circulating cell-free DNA (cfDNA) and cell-free RNA (cfRNA). Leveraging the simplicity of a blood draw, liquid biopsy emerges as a powerful tool, unravelling insights from cancer predisposition to the aftermath of traumatic brain injuries.
Applications
The Crucial Role of Draw-Time Analysis
In the realm of liquid biopsy, timing is everything. Diseases linked to elevated circulating cfDNA and cfRNA demand precise analysis, necessitating a choice: immediate evaluation or the adoption of a stabilisation tube. Stabilising blood samples, ensures an accurate reflection of what is in the patient’s circulation. Without stabilisation, samples deteriorate, releasing genomic DNA (gDNA), extracellular vesicles (EVs), and EV-associated cfRNA due to white and red blood cell breakdown. This degradation introduces non-specific increases in analytes, clouding the original sample's analysis.
Introducing Nucleic Acid BCT
While traditional storage methods, like EDTA tubes, offer brief sample integrity, they fall short in long-term room temperature storage. The new Nucleic Acid BCT™, is a game-changer in preserving nucleic acid concentrations, maintaining analyte levels at draw-time concentrations for up to 7 days at room temperature. This empowers laboratories to shift focus from degradation concerns to data analysis.
The advantages extend far beyond precise data. Nucleic Acid BCT liberates laboratories from cold storage constraints, slashing shipping and handling costs. Ideal for groups relying on off-site laboratories, it extends storage time without compromising analysis. Moreover, it amplifies laboratory efficiency, allowing batches of samples to be processed weekly, contrasting with the immediate attention demanded by traditional tubes.
All your workflows in one tube!
Features
Stabilises sample for cfDNA, EVs and cfRNA
7-day sample stability when stored at room temperature
Compatible with commercially available total plasma nucleic acid isolation kits
Compatible with standard low input RNA sequencing library prep kits
Isolated nucleic acids are suitable for downstream applications
Benefits
Limits degradation of white and red blood cells, providing sample integrity during storage, shipping and handling of blood samples
Room temperature storage reduces costs and complications associated with cold chain shipping
Eliminates the need for immediate plasma preparation
One plasma isolation protocol for both cell-free DNA and cell-free RNA
95 kPa pressure differential tested for compliance with UN3373-Pl650 and 49 CFR 173.196(a)(6) specimen transport regulations
